Disruption of the dopamine D2 receptor impairs insulin secretion and causes glucose intolerance

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The relationship between antidopaminergic drugs and glucose has not been extensively studied, even though chronic neuroleptic treatment causes hyperinsulinemia in normal subjects or is associated with diabetes in psychiatric patients. We sought to evaluate dopamine D2 receptor (D2R) participation in...

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Autores principales:	García-Tornadú, I., Ornstein, A.M., Chamson-Reig, A., Wheeler, M.B., Hill, D.J., Arany, E., Rubinstein, M., Becu-Villalobos, D.
Formato:	Artículo publishedVersion
Publicado:	2010
Materias:	cabergoline dopamine 2 receptor haloperidol animal cell animal experiment animal model animal tissue article cell division cell isolation drug mechanism glucose homeostasis glucose intolerance immunohistochemistry in vitro study in vivo study insulin release insulin tolerance test male mouse nonhuman pancreas function pancreas islet beta cell pancreas islet cell priority journal Analysis of Variance Animals Blood Glucose Cell Proliferation Dopamine Agonists Dopamine Antagonists Ergolines Female Glucose Glucose Intolerance Haloperidol Immunohistochemistry Insulin Insulin-Like Growth Factor I Male Mice Mice, Knockout Pancreas Prolactin Radioimmunoassay Receptors, Dopamine D2 Time Factors
Acceso en línea:	http://hdl.handle.net/20.500.12110/paper_00137227_v151_n4_p1441_GarciaTornadu https://repositoriouba.sisbi.uba.ar/gsdl/cgi-bin/library.cgi?a=d&c=artiaex&d=paper_00137227_v151_n4_p1441_GarciaTornadu_oai
Aporte de:	Repositorio Digital de la Universidad de Buenos Aires (UBA) de Universidad de Buenos Aires

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