Estudio de factores que regulan la biotransformación del arsénico en poblaciones expuestas crónicamente
The influence, on arsenic (As) urinary metabolic profile, of the level of As exposure was evaluated on chronic exposed inhabitants of several locations of the Chaco Pampean Plains in Argentina. Urinary As metabolic profile (inorganic As, monomethylarsonic acid and dimethylarsinic acid) was evaluated...
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| Formato: | Tesis doctoral acceptedVersion |
| Lenguaje: | Español |
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Facultad de Farmacia y Bioquímica
2016
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| Acceso en línea: | http://repositoriouba.sisbi.uba.ar/gsdl/cgi-bin/library.cgi?a=d&c=posgraafa&cl=CL1&d=HWA_1375 http://repositoriouba.sisbi.uba.ar/gsdl/collect/posgraafa/index/assoc/HWA_1375.dir/1375.PDF |
| Aporte de: |
| Sumario: | The influence, on arsenic (As) urinary metabolic profile, of the level of As exposure was evaluated on chronic exposed inhabitants of several locations of the Chaco Pampean Plains in Argentina. Urinary As metabolic profile (inorganic As, monomethylarsonic acid and dimethylarsinic acid) was evaluated and the sum of all metabolites was used as a measure of the level of exposure. The presence of three polymorphisms: T860C on the arsenite methyltransferase and C677T and A1298C on methylenetetrahydrofolate reductase encoding genes were also investigated. A clear influence of age, gender, level of As exposure and presence of the T860C polymorphism was observed on As metabolic profile. No influence of C677T or A1298C polymorphism was observed. The influence of the level of exposure on urinary As metabolic profile showed to be different between children and adults, males and females and individuals carrying the wild type and the heterozygous genotypes of the T860C polymorphism. The level of exposure should be reduced not only to lower the deleterious health effects of As, but also because the ability to metabolize of certain population subgroups, could be negatively affected increasing the risk to develop As-related diseases. |
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