Comparative effects of natural products on ischemia-reperfusion injury: relation to their "in vitro" antioxidant capacity

Our aim was to compare the effects of a non-alcoholic Cabernet-Sauvignon (CS), Malbec (M), Merlot blend (BW) red wine extracts, <i>Ilex paraguariensis</i> (Ip) or <i>Ilex brasiliensis</i> (Ib) aqueous extracts, <i>Vaccinium meridionale</i> Swartz (mortiño) ferme...

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Autores principales: Fantinelli, Juliana Catalina, González Arbeláez, Luisa Fernanda, Ciocci Pardo, Alejandro, Schinella, Guillermo Raúl, Mosca, Susana María
Formato: Articulo
Lenguaje:Inglés
Publicado: 2016
Materias:
Medicina
natural products extracts
antioxidant capacity,
ischemia-reperfusion
nitric oxide
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/98495
https://ri.conicet.gov.ar/11336/54385
http://www.blacpma.usach.cl/revista-numero/comparative-effects-natural-products-ischemia-reperfusion-injury-relation-their-vitro
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-98495
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Medicina
natural products extracts
antioxidant capacity,
ischemia-reperfusion
nitric oxide
spellingShingle Medicina
natural products extracts
antioxidant capacity,
ischemia-reperfusion
nitric oxide
Fantinelli, Juliana Catalina
González Arbeláez, Luisa Fernanda
Ciocci Pardo, Alejandro
Schinella, Guillermo Raúl
Mosca, Susana María
Comparative effects of natural products on ischemia-reperfusion injury: relation to their "in vitro" antioxidant capacity
topic_facet Medicina
natural products extracts
antioxidant capacity,
ischemia-reperfusion
nitric oxide
description Our aim was to compare the effects of a non-alcoholic Cabernet-Sauvignon (CS), Malbec (M), Merlot blend (BW) red wine extracts, <i>Ilex paraguariensis</i> (Ip) or <i>Ilex brasiliensis</i> (Ib) aqueous extracts, <i>Vaccinium meridionale</i> Swartz (mortiño) fermented extract (FE) , berry juice (BJ) and polyphenols-riched fractions of cocoa(PFC) against reperfusion injury. Isolated rat hearts were submitted to 20 min of global ischemia (GI) and 30 min of reperfusion (R). Other hearts were treated 10 min before GI and first 10 min of R with the extracts. CS, M, Ip, Ib and FE attenuated the myocardial dysfunction and oxidative damage whereas BW, BJ and PFC were ineffective. Paradoxically, PFR had the highest and BW similar scavenging activity than protective extracts. The beneficial actions were lost when nitric oxide synthase (NOS) was inhibited. These data indicate that "<i>in vitro</i>" antioxidant capacity of natural products is not primarily responsible for the cardioprotection being involved NO-dependent pathways.
format Articulo
Articulo
author Fantinelli, Juliana Catalina
González Arbeláez, Luisa Fernanda
Ciocci Pardo, Alejandro
Schinella, Guillermo Raúl
Mosca, Susana María
author_facet Fantinelli, Juliana Catalina
González Arbeláez, Luisa Fernanda
Ciocci Pardo, Alejandro
Schinella, Guillermo Raúl
Mosca, Susana María
author_sort Fantinelli, Juliana Catalina
title Comparative effects of natural products on ischemia-reperfusion injury: relation to their "in vitro" antioxidant capacity
title_short Comparative effects of natural products on ischemia-reperfusion injury: relation to their "in vitro" antioxidant capacity
title_full Comparative effects of natural products on ischemia-reperfusion injury: relation to their "in vitro" antioxidant capacity
title_fullStr Comparative effects of natural products on ischemia-reperfusion injury: relation to their "in vitro" antioxidant capacity
title_full_unstemmed Comparative effects of natural products on ischemia-reperfusion injury: relation to their "in vitro" antioxidant capacity
title_sort comparative effects of natural products on ischemia-reperfusion injury: relation to their "in vitro" antioxidant capacity
publishDate 2016
url http://sedici.unlp.edu.ar/handle/10915/98495
https://ri.conicet.gov.ar/11336/54385
http://www.blacpma.usach.cl/revista-numero/comparative-effects-natural-products-ischemia-reperfusion-injury-relation-their-vitro
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