Alkaloid isomerization induced by spray drying of Uncaria tomentosa bark extracts

Cat's claw (Uncaria tomentosa (Willd) DC) is an alkaloid rich-liana from the Peruvian Amazon rainforest. Regarding several oxindole alkaloids from cat's claw bark, the isomerization induced by pH, temperature and solvent polarity is reported in the literature. Some industrial drying proces...

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Autores principales: Pavei, Cabral, Borré, Gustavo Luis, Kaiser, Samuel, González Ortega, George
Formato: Articulo Comunicacion
Lenguaje:Inglés
Publicado: 2011
Materias:
Farmacia
Extractos Vegetales
alkaloids; column liquid chromatography isomerization; spray dried extracts; Uncaria tomentosa
Técnicas de Química Analítica
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/8189
http://www.latamjpharm.org/resumenes/30/3/LAJOP_30_3_2_15.pdf
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-8189
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Farmacia
Extractos Vegetales
alkaloids; column liquid chromatography isomerization; spray dried extracts; Uncaria tomentosa
Técnicas de Química Analítica
spellingShingle Farmacia
Extractos Vegetales
alkaloids; column liquid chromatography isomerization; spray dried extracts; Uncaria tomentosa
Técnicas de Química Analítica
Pavei, Cabral
Borré, Gustavo Luis
Kaiser, Samuel
González Ortega, George
Alkaloid isomerization induced by spray drying of Uncaria tomentosa bark extracts
topic_facet Farmacia
Extractos Vegetales
alkaloids; column liquid chromatography isomerization; spray dried extracts; Uncaria tomentosa
Técnicas de Química Analítica
description Cat's claw (Uncaria tomentosa (Willd) DC) is an alkaloid rich-liana from the Peruvian Amazon rainforest. Regarding several oxindole alkaloids from cat's claw bark, the isomerization induced by pH, temperature and solvent polarity is reported in the literature. Some industrial drying processes, such as spray drying, can provide therefore favorable conditions of heating and moisture for isomerization, and it is expected to have effects on the alkaloid composition during technological processing. In this work we focused on the effect of spray drying on the isomerization of alkaloids of dried extracts obtained from Uncaria tomentosa bark. High isomerization levels were observed in all dried extracts. A loss in mitraphylline (15%) and pteropodine (12%) content is related to an equivalent content increase of isomitraphylline and isopteropodine, respectively. Since different biological and pharmacological activities had been ascribed to these alkaloids, the influence of the thermal effect inherent to the spray drying technique and excipient type should be worth of special attention.
format Articulo
Comunicacion
author Pavei, Cabral
Borré, Gustavo Luis
Kaiser, Samuel
González Ortega, George
author_facet Pavei, Cabral
Borré, Gustavo Luis
Kaiser, Samuel
González Ortega, George
author_sort Pavei, Cabral
title Alkaloid isomerization induced by spray drying of Uncaria tomentosa bark extracts
title_short Alkaloid isomerization induced by spray drying of Uncaria tomentosa bark extracts
title_full Alkaloid isomerization induced by spray drying of Uncaria tomentosa bark extracts
title_fullStr Alkaloid isomerization induced by spray drying of Uncaria tomentosa bark extracts
title_full_unstemmed Alkaloid isomerization induced by spray drying of Uncaria tomentosa bark extracts
title_sort alkaloid isomerization induced by spray drying of uncaria tomentosa bark extracts
publishDate 2011
url http://sedici.unlp.edu.ar/handle/10915/8189
http://www.latamjpharm.org/resumenes/30/3/LAJOP_30_3_2_15.pdf
work_keys_str_mv AT paveicabral alkaloidisomerizationinducedbyspraydryingofuncariatomentosabarkextracts
AT borregustavoluis alkaloidisomerizationinducedbyspraydryingofuncariatomentosabarkextracts
AT kaisersamuel alkaloidisomerizationinducedbyspraydryingofuncariatomentosabarkextracts
AT gonzalezortegageorge alkaloidisomerizationinducedbyspraydryingofuncariatomentosabarkextracts
bdutipo_str Repositorios
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