Antimicrobial and cytotoxic activity of fruit extract from <i>Syzygium cumini</i> (L.) Skeels

The aim of the present study was to evaluate the antimicrobial and cytotoxic activity of the ethanolic extract of S. cumini according to the Clinical and Laboratory Standards Institute reference method (with modifications), determining the minimal inhibitory and lethal concentration. Activity agains...

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Autores principales: Migliato, Ketylin F., Mello, João Carlos Palazzo de, Higa, Olga Z., Rodas, Andrea C. D., Corrêa, Marcos A., Mendes Giannini, Maria J.S., Fusco Almeida, Ana M., Pizzolitto, Antonio C., Salgado, Hérida R.N.
Formato: Articulo
Lenguaje:Inglés
Publicado: 2010
Materias:
Farmacia
Farmacología
antibacterial; antifungal; antimicrobial activity; cytotoxic activity; jambolan; minimum inhibitory concentration; minimal lethal concentration; Syzygium cumini
Citotoxicidad
Plantas medicinales
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/7974
http://www.latamjpharm.org/resumenes/29/5/LAJOP_29_5_1_13.pdf
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-7974
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Farmacia
Farmacología
antibacterial; antifungal; antimicrobial activity; cytotoxic activity; jambolan; minimum inhibitory concentration; minimal lethal concentration; Syzygium cumini
Citotoxicidad
Plantas medicinales
spellingShingle Farmacia
Farmacología
antibacterial; antifungal; antimicrobial activity; cytotoxic activity; jambolan; minimum inhibitory concentration; minimal lethal concentration; Syzygium cumini
Citotoxicidad
Plantas medicinales
Migliato, Ketylin F.
Mello, João Carlos Palazzo de
Higa, Olga Z.
Rodas, Andrea C. D.
Corrêa, Marcos A.
Mendes Giannini, Maria J.S.
Fusco Almeida, Ana M.
Pizzolitto, Antonio C.
Salgado, Hérida R.N.
Antimicrobial and cytotoxic activity of fruit extract from <i>Syzygium cumini</i> (L.) Skeels
topic_facet Farmacia
Farmacología
antibacterial; antifungal; antimicrobial activity; cytotoxic activity; jambolan; minimum inhibitory concentration; minimal lethal concentration; Syzygium cumini
Citotoxicidad
Plantas medicinales
description The aim of the present study was to evaluate the antimicrobial and cytotoxic activity of the ethanolic extract of S. cumini according to the Clinical and Laboratory Standards Institute reference method (with modifications), determining the minimal inhibitory and lethal concentration. Activity against Gram-positive (Staphylococcus aureus and S. epidermidis), Gram-negative (Pseudomonas aeruginosa) and yeast of Candida sp and Cryptococcus neoformans was evaluated. The effects of the fruit extract were examined in hamster cells ovaries in concentrations ranging from 1250.0 a 4.9 μg/ml, measuring the r educ t ion of the t e t razol ium sal t 3- (4,5-dime thyl thiazol -2-yl ) -5- (3- carboxyme thoxyphenyl ) -2- (4- sulphophenyl)-2H-tetrazolium. The extract showed both bactericidal and fungicidal activity among the various microorganisms tested and the MIC ranging from 7.8 to 250 μg/ml. The MIC, MBC and MFC should values that were similar for all the microorganisms. Cytotoxicity index of the dried extract corresponded to the concentration of 400 μg/ml. The extract could potentially be used in topical antimicrobial products. Thus, the activity of extract was potent to bacteria and mainly to non-albicans species and C. neoformans.
format Articulo
Articulo
author Migliato, Ketylin F.
Mello, João Carlos Palazzo de
Higa, Olga Z.
Rodas, Andrea C. D.
Corrêa, Marcos A.
Mendes Giannini, Maria J.S.
Fusco Almeida, Ana M.
Pizzolitto, Antonio C.
Salgado, Hérida R.N.
author_facet Migliato, Ketylin F.
Mello, João Carlos Palazzo de
Higa, Olga Z.
Rodas, Andrea C. D.
Corrêa, Marcos A.
Mendes Giannini, Maria J.S.
Fusco Almeida, Ana M.
Pizzolitto, Antonio C.
Salgado, Hérida R.N.
author_sort Migliato, Ketylin F.
title Antimicrobial and cytotoxic activity of fruit extract from <i>Syzygium cumini</i> (L.) Skeels
title_short Antimicrobial and cytotoxic activity of fruit extract from <i>Syzygium cumini</i> (L.) Skeels
title_full Antimicrobial and cytotoxic activity of fruit extract from <i>Syzygium cumini</i> (L.) Skeels
title_fullStr Antimicrobial and cytotoxic activity of fruit extract from <i>Syzygium cumini</i> (L.) Skeels
title_full_unstemmed Antimicrobial and cytotoxic activity of fruit extract from <i>Syzygium cumini</i> (L.) Skeels
title_sort antimicrobial and cytotoxic activity of fruit extract from <i>syzygium cumini</i> (l.) skeels
publishDate 2010
url http://sedici.unlp.edu.ar/handle/10915/7974
http://www.latamjpharm.org/resumenes/29/5/LAJOP_29_5_1_13.pdf
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