Analgesic and anti-inflammatory activities of salicylaldehyde 2-chlorobenzoyl hydrazone (H2LASSBio-466), salicylaldehyde 4-chlorobenzoyl hydrazone (H 2LASSBio-1064) and their zinc(II) complexes

Salicylaldehyde 2-chlorobenzoyl hydrazone (H 2LASSBio-466), salicylaldehyde 4-chlorobenzoyl hydrazone (H 2LASSBio-1064) and their complexes [Zn(LASSBio- 466)H 2O] 2 (1) and [Zn(HLASSBio-1064)Cl]...

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Autores principales: Júnior, Walfrido Bispo, Alexandre Moreira, Magna S., Alves, Marina A., Pérez Rebolledo, Anayive, Parrilha, Gabrieli L., Castellano, Eduardo Ernesto, Piro, Oscar Enrique, Barreiro, Eliezer Jesus de Lacerda, Lima, Lídia Moreira, Beraldo, Heloisa
Formato: Articulo
Lenguaje:Inglés
Publicado: 2011
Materias:
Ciencias Exactas
Química
acylhydrazones
analgesic agent
analgesic activity
antiinflammatory agent
anti-inflammatory activity
dipyrone
zinc (II) complexes
formaldehyde
hydrazone derivative
morphine
salicylaldehyde
metabolism
pathophysiology
peritonitis
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/35112
http://www.mdpi.com/1420-3049/16/8/6902
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-35112
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Ciencias Exactas
Química
acylhydrazones
analgesic agent
analgesic activity
antiinflammatory agent
anti-inflammatory activity
dipyrone
zinc (II) complexes
formaldehyde
hydrazone derivative
morphine
salicylaldehyde
metabolism
pathophysiology
peritonitis
spellingShingle Ciencias Exactas
Química
acylhydrazones
analgesic agent
analgesic activity
antiinflammatory agent
anti-inflammatory activity
dipyrone
zinc (II) complexes
formaldehyde
hydrazone derivative
morphine
salicylaldehyde
metabolism
pathophysiology
peritonitis
Júnior, Walfrido Bispo
Alexandre Moreira, Magna S.
Alves, Marina A.
Pérez Rebolledo, Anayive
Parrilha, Gabrieli L.
Castellano, Eduardo Ernesto
Piro, Oscar Enrique
Barreiro, Eliezer Jesus de Lacerda
Lima, Lídia Moreira
Beraldo, Heloisa
Analgesic and anti-inflammatory activities of salicylaldehyde 2-chlorobenzoyl hydrazone (H2LASSBio-466), salicylaldehyde 4-chlorobenzoyl hydrazone (H 2LASSBio-1064) and their zinc(II) complexes
topic_facet Ciencias Exactas
Química
acylhydrazones
analgesic agent
analgesic activity
antiinflammatory agent
anti-inflammatory activity
dipyrone
zinc (II) complexes
formaldehyde
hydrazone derivative
morphine
salicylaldehyde
metabolism
pathophysiology
peritonitis
description Salicylaldehyde 2-chlorobenzoyl hydrazone (H 2LASSBio-466), salicylaldehyde 4-chlorobenzoyl hydrazone (H 2LASSBio-1064) and their complexes [Zn(LASSBio- 466)H 2O] 2 (1) and [Zn(HLASSBio-1064)Cl] 2 (2) were evaluated in animal models of peripheral and central nociception, and acute inflammation. All studied compounds significantly inhibited acetic acid-induced writhing response. Upon coordination the antinociceptive activity was favored in the complex 1. H 2LASSBio-466 inhibited only the first phase of the formalin test, while 1 was active in the second phase, like indomethacin, indicating its ability to inhibit nociception associated with the inflammatory response. Hence coordination to zinc(II) altered the pharmacological profile of H 2LASSBio-466. H2LASSBio-1064 inhibited both phases but this effect was not improved by coordination. The studied compounds did not increase the latency of response in the hot plate model, indicating their lack of central anti-nociceptive activity. All compounds showed levels of inhibition of zymosan-induced peritonitis comparable or superior to indomethacin, indicating an expressive anti-inflammatory profile.
format Articulo
Articulo
author Júnior, Walfrido Bispo
Alexandre Moreira, Magna S.
Alves, Marina A.
Pérez Rebolledo, Anayive
Parrilha, Gabrieli L.
Castellano, Eduardo Ernesto
Piro, Oscar Enrique
Barreiro, Eliezer Jesus de Lacerda
Lima, Lídia Moreira
Beraldo, Heloisa
author_facet Júnior, Walfrido Bispo
Alexandre Moreira, Magna S.
Alves, Marina A.
Pérez Rebolledo, Anayive
Parrilha, Gabrieli L.
Castellano, Eduardo Ernesto
Piro, Oscar Enrique
Barreiro, Eliezer Jesus de Lacerda
Lima, Lídia Moreira
Beraldo, Heloisa
author_sort Júnior, Walfrido Bispo
title Analgesic and anti-inflammatory activities of salicylaldehyde 2-chlorobenzoyl hydrazone (H2LASSBio-466), salicylaldehyde 4-chlorobenzoyl hydrazone (H 2LASSBio-1064) and their zinc(II) complexes
title_short Analgesic and anti-inflammatory activities of salicylaldehyde 2-chlorobenzoyl hydrazone (H2LASSBio-466), salicylaldehyde 4-chlorobenzoyl hydrazone (H 2LASSBio-1064) and their zinc(II) complexes
title_full Analgesic and anti-inflammatory activities of salicylaldehyde 2-chlorobenzoyl hydrazone (H2LASSBio-466), salicylaldehyde 4-chlorobenzoyl hydrazone (H 2LASSBio-1064) and their zinc(II) complexes
title_fullStr Analgesic and anti-inflammatory activities of salicylaldehyde 2-chlorobenzoyl hydrazone (H2LASSBio-466), salicylaldehyde 4-chlorobenzoyl hydrazone (H 2LASSBio-1064) and their zinc(II) complexes
title_full_unstemmed Analgesic and anti-inflammatory activities of salicylaldehyde 2-chlorobenzoyl hydrazone (H2LASSBio-466), salicylaldehyde 4-chlorobenzoyl hydrazone (H 2LASSBio-1064) and their zinc(II) complexes
title_sort analgesic and anti-inflammatory activities of salicylaldehyde 2-chlorobenzoyl hydrazone (h2lassbio-466), salicylaldehyde 4-chlorobenzoyl hydrazone (h 2lassbio-1064) and their zinc(ii) complexes
publishDate 2011
url http://sedici.unlp.edu.ar/handle/10915/35112
http://www.mdpi.com/1420-3049/16/8/6902
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