Mesenchymal stromal cells in chronic respiratory diseases: What’s new?

Chronic respiratory diseases, including asthma and chronic obstructive pulmonary disease (COPD), are a major health issue worldwide due to their growing prevalence and high economic costs, which include prolonged medication use and frequent hospitalizations. Both asthma and COPD are incurable, and e...

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Detalles Bibliográficos
Autores principales: Antunes, Mariana A., Weiss, Daniel J., Rocco, Patricia R. M.
Formato: Articulo Revision
Lenguaje:Inglés
Publicado: 2015
Materias:
Ciencias Médicas
mesenchymal stromal cells
COPD
asthma
acute respiratory distress syndrome
pulmonary arterial hypertension
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/127769
https://pmr.safisiol.org.ar/archive/id/77
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-127769
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Ciencias Médicas
mesenchymal stromal cells
COPD
asthma
acute respiratory distress syndrome
pulmonary arterial hypertension
spellingShingle Ciencias Médicas
mesenchymal stromal cells
COPD
asthma
acute respiratory distress syndrome
pulmonary arterial hypertension
Antunes, Mariana A.
Weiss, Daniel J.
Rocco, Patricia R. M.
Mesenchymal stromal cells in chronic respiratory diseases: What’s new?
topic_facet Ciencias Médicas
mesenchymal stromal cells
COPD
asthma
acute respiratory distress syndrome
pulmonary arterial hypertension
description Chronic respiratory diseases, including asthma and chronic obstructive pulmonary disease (COPD), are a major health issue worldwide due to their growing prevalence and high economic costs, which include prolonged medication use and frequent hospitalizations. Both asthma and COPD are incurable, and each is characterized by chronic inflammation, tissue remodeling, and ultrastructural alterations that might not be amenable to available therapies. Mesenchymal stromal cells (MSCs) are non-hematopoietic, immunosuppressive cells found in bone marrow, adipose tissue, placenta, and other tissues and have demonstrated anti-inflammatory actions in a number of preclinical models of asthma and COPD. Although the entire repertoire of action of MSCs has not been elucidated, there is growing interest in the potential clinical utility of MSC-based cell therapy in chronic respiratory diseases. The present review will focus on the most recent mechanisms that have been elucidated from preclinical studies in asthma and COPD. In addition, a comprehensive review of clinical trials conducted to date will be presented.
format Articulo
Revision
author Antunes, Mariana A.
Weiss, Daniel J.
Rocco, Patricia R. M.
author_facet Antunes, Mariana A.
Weiss, Daniel J.
Rocco, Patricia R. M.
author_sort Antunes, Mariana A.
title Mesenchymal stromal cells in chronic respiratory diseases: What’s new?
title_short Mesenchymal stromal cells in chronic respiratory diseases: What’s new?
title_full Mesenchymal stromal cells in chronic respiratory diseases: What’s new?
title_fullStr Mesenchymal stromal cells in chronic respiratory diseases: What’s new?
title_full_unstemmed Mesenchymal stromal cells in chronic respiratory diseases: What’s new?
title_sort mesenchymal stromal cells in chronic respiratory diseases: what’s new?
publishDate 2015
url http://sedici.unlp.edu.ar/handle/10915/127769
https://pmr.safisiol.org.ar/archive/id/77
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AT roccopatriciarm mesenchymalstromalcellsinchronicrespiratorydiseaseswhatsnew
bdutipo_str Repositorios
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