Effect of lead acetate on the in vitro engulfment and killing capability of toad (<i>Bufo arenarum</i>) neutrophils

Lead is an element of risk for the environment and human health and has harmful effects that may exceed those of other inorganic toxicants. The immune system is one ofthe targets of lead. Its immunomodulatory actions depend on the level of exposure, and it has been demonstrated that environmental am...

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Detalles Bibliográficos
Autores principales: Rosenberg, Carolina Elena, Fink, Nilda Esther, Arrieta, Marcos A., Salibian, Alfredo
Formato: Articulo
Lenguaje:Inglés
Publicado: 2003
Materias:
Biología
Lead
Phagocytosis
Lytic activity
Candicidal activity
Polymorphonuclear cells
Neutrophils
Candida pseudotropicalis
Amphibia
Bufo arenarum
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/114716
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-114716
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Biología
Lead
Phagocytosis
Lytic activity
Candicidal activity
Polymorphonuclear cells
Neutrophils
Candida pseudotropicalis
Amphibia
Bufo arenarum
spellingShingle Biología
Lead
Phagocytosis
Lytic activity
Candicidal activity
Polymorphonuclear cells
Neutrophils
Candida pseudotropicalis
Amphibia
Bufo arenarum
Rosenberg, Carolina Elena
Fink, Nilda Esther
Arrieta, Marcos A.
Salibian, Alfredo
Effect of lead acetate on the in vitro engulfment and killing capability of toad (<i>Bufo arenarum</i>) neutrophils
topic_facet Biología
Lead
Phagocytosis
Lytic activity
Candicidal activity
Polymorphonuclear cells
Neutrophils
Candida pseudotropicalis
Amphibia
Bufo arenarum
description Lead is an element of risk for the environment and human health and has harmful effects that may exceed those of other inorganic toxicants. The immune system is one ofthe targets of lead. Its immunomodulatory actions depend on the level of exposure, and it has been demonstrated that environmental amounts of the metal alter immune function. Very little information is available regarding the effect of the metal on different aspects of the immune system of lower vertebrates, in particular of amphibians. The aim of this study was to investigate the effect of sublethal lead (as acetate) on the function of polymorphonuclear cells of Bufo arenarum. The results revealed that phagocytic and lytic functions ofthe adherent blood cells collected from sublethal lead-injected toads and incubated with suspensions of Candida pseudotropicalis were affected negatively. The decrease of the phagocytic activity was correlated with increased blood lead levels (P-0.0001). Additional information referred to the total and differential leukocyte counts was presented; the only difference found was in the number of blast-like cells that resulted augmented in the samples of lead-injected toads. It was concluded that the evaluation ofthese parameters might be a reliable tool for the biological monitoring of the immune status of amphibians.
format Articulo
Articulo
author Rosenberg, Carolina Elena
Fink, Nilda Esther
Arrieta, Marcos A.
Salibian, Alfredo
author_facet Rosenberg, Carolina Elena
Fink, Nilda Esther
Arrieta, Marcos A.
Salibian, Alfredo
author_sort Rosenberg, Carolina Elena
title Effect of lead acetate on the in vitro engulfment and killing capability of toad (<i>Bufo arenarum</i>) neutrophils
title_short Effect of lead acetate on the in vitro engulfment and killing capability of toad (<i>Bufo arenarum</i>) neutrophils
title_full Effect of lead acetate on the in vitro engulfment and killing capability of toad (<i>Bufo arenarum</i>) neutrophils
title_fullStr Effect of lead acetate on the in vitro engulfment and killing capability of toad (<i>Bufo arenarum</i>) neutrophils
title_full_unstemmed Effect of lead acetate on the in vitro engulfment and killing capability of toad (<i>Bufo arenarum</i>) neutrophils
title_sort effect of lead acetate on the in vitro engulfment and killing capability of toad (<i>bufo arenarum</i>) neutrophils
publishDate 2003
url http://sedici.unlp.edu.ar/handle/10915/114716
work_keys_str_mv AT rosenbergcarolinaelena effectofleadacetateontheinvitroengulfmentandkillingcapabilityoftoadibufoarenarumineutrophils
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AT arrietamarcosa effectofleadacetateontheinvitroengulfmentandkillingcapabilityoftoadibufoarenarumineutrophils
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bdutipo_str Repositorios
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