A general reaction mechanism for carbapenem hydrolysis by mononuclear and binuclear metallo-β-lactamases
Carbapenem-resistant Enterobacteriaceae threaten human health, since carbapenems are last resort drugs for infections by such organisms. Metallo-β-lactamases (MβLs) are the main mechanism of resistance against carbapenems. Clinically approved inhibitors of MBLs are currently unavailable as design...
Guardado en:
Autores principales: | Lisa, María Natalia, Palacios, Antonela R., Aitha, Mahesh, González, Mariano M., Moreno, Diego M., Crowder, Michael W., Bonomo, Robert A., Spencer, James, Tierney, David L., Llarrull, Leticia I., Vila, Alejandro J. |
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Formato: | article artículo publishedVersion |
Lenguaje: | Inglés |
Publicado: |
Nature
2021
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Materias: | |
Acceso en línea: | http://hdl.handle.net/2133/20014 http://hdl.handle.net/2133/20014 |
Aporte de: |
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