Death of adrenocortical cells during murine acute T. cruzi infection is not associated with TNF-R1 signaling but mostly with the type II pathway of Fas-mediated apoptosis

Earlier studies from our laboratory demonstrated that acute experimental Trypanosoma cruzi infection promotes an intense inflammation along with a sepsis-like dysregulated adrenal response characterized by normal levels of ACTH with raised glucocorticoid secretion. Inflammation was also known to res...

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Autores principales: Pérez, Ana Rosa, Lambertucci, Flavia, González, Florencia Belén, Roggero, Eduardo Angel, Bottasso, Oscar, de Meis, Juliana, Ronco, Maria Teresa, Villar, Silvina Raquel
Formato: article artículo acceptedVersion
Lenguaje:Inglés
Publicado: Academic Press Inc Elsevier Science 2019
Materias:
Adrenal glands
Glucocorticoid
Apoptosis
Trypanosoma cruzi
Tumor necrosis factor alpha
Acceso en línea:http://hdl.handle.net/2133/14298
http://hdl.handle.net/2133/14298
Aporte de:
Repositorio Hipermedial de la Universidad Nacional de Rosario (UNR) de Universidad Nacional de Rosario
id I15-R121-2133-14298
record_format dspace
institution Universidad Nacional de Rosario
institution_str I-15
repository_str R-121
collection Repositorio Hipermedial de la Universidad Nacional de Rosario (UNR)
language Inglés
orig_language_str_mv eng
topic Adrenal glands
Glucocorticoid
Apoptosis
Trypanosoma cruzi
Tumor necrosis factor alpha
spellingShingle Adrenal glands
Glucocorticoid
Apoptosis
Trypanosoma cruzi
Tumor necrosis factor alpha
Pérez, Ana Rosa
Lambertucci, Flavia
González, Florencia Belén
Roggero, Eduardo Angel
Bottasso, Oscar
de Meis, Juliana
Ronco, Maria Teresa
Villar, Silvina Raquel
Death of adrenocortical cells during murine acute T. cruzi infection is not associated with TNF-R1 signaling but mostly with the type II pathway of Fas-mediated apoptosis
topic_facet Adrenal glands
Glucocorticoid
Apoptosis
Trypanosoma cruzi
Tumor necrosis factor alpha
description Earlier studies from our laboratory demonstrated that acute experimental Trypanosoma cruzi infection promotes an intense inflammation along with a sepsis-like dysregulated adrenal response characterized by normal levels of ACTH with raised glucocorticoid secretion. Inflammation was also known to result in adrenal cell apoptosis, which in turn may influence HPA axis uncoupling. To explore factors and pathways which may be involved in the apoptosis of adrenal cells, together with its impact on the functionality of the gland, we carried out a series of studies in mice lacking death receptors, such as TNF-R1 (C57BL/6-Tnfrsf1a tm1Imx or TNF-R1−/−) or Fas ligand (C57BL/6 Fas-deficient lpr mice), undergoing acute T. cruzi infection. Here we demonstrate that the late hypercorticosterolism seen in C57BL/6 mice during acute T. cruzi infection coexists with and hyperplasia and hypertrophy of zona fasciculata, paralleled by increased number of apoptotic cells. Apoptosis seems to be mediated mainly by the type II pathway of Fas-mediated apoptosis, which engages the mitochondrial pathway of apoptosis triggering the cytochrome c release to increase caspase-3 activation. Fas-induced apoptosis of adrenocortical cells is also related with an exacerbated production of intra-adrenal cytokines that probably maintain the late supply of adrenal hormones during host response. Present results shed light on the molecular mechanisms dealing with these phenomena which are crucial not only for the development of interventions attempting to avoid adrenal dysfunction, but also for its wide occurrence in other infectious-based critical illnesses.
format article
artículo
acceptedVersion
author Pérez, Ana Rosa
Lambertucci, Flavia
González, Florencia Belén
Roggero, Eduardo Angel
Bottasso, Oscar
de Meis, Juliana
Ronco, Maria Teresa
Villar, Silvina Raquel
author_facet Pérez, Ana Rosa
Lambertucci, Flavia
González, Florencia Belén
Roggero, Eduardo Angel
Bottasso, Oscar
de Meis, Juliana
Ronco, Maria Teresa
Villar, Silvina Raquel
author_sort Pérez, Ana Rosa
title Death of adrenocortical cells during murine acute T. cruzi infection is not associated with TNF-R1 signaling but mostly with the type II pathway of Fas-mediated apoptosis
title_short Death of adrenocortical cells during murine acute T. cruzi infection is not associated with TNF-R1 signaling but mostly with the type II pathway of Fas-mediated apoptosis
title_full Death of adrenocortical cells during murine acute T. cruzi infection is not associated with TNF-R1 signaling but mostly with the type II pathway of Fas-mediated apoptosis
title_fullStr Death of adrenocortical cells during murine acute T. cruzi infection is not associated with TNF-R1 signaling but mostly with the type II pathway of Fas-mediated apoptosis
title_full_unstemmed Death of adrenocortical cells during murine acute T. cruzi infection is not associated with TNF-R1 signaling but mostly with the type II pathway of Fas-mediated apoptosis
title_sort death of adrenocortical cells during murine acute t. cruzi infection is not associated with tnf-r1 signaling but mostly with the type ii pathway of fas-mediated apoptosis
publisher Academic Press Inc Elsevier Science
publishDate 2019
url http://hdl.handle.net/2133/14298
http://hdl.handle.net/2133/14298
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