Clinical and epidemiological characteristics of patients hospitalized for SARS-CoV-2 infection in two hospitals in Córdoba: SARS-CoV-2 infection in hospitalized patients

Introduction: COVID-19 disease shows a marked heterogeneity in its clinical course, with descriptions of some factors associated with a worse prognosis. Knowledge of the disease behavior in the local scenario is relevant to allow a better approach.  Methods: Retrospective study in...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Saad, Emanuel José, Correa Barovero, María Antonella, Marucco , Federico Ariel, Rodríguez Bonazzi, Silvina Trinidad, Tarditi Barra, Ayelén, Zlotogora, Melani, Villada, Sofía María, Douthat y Barrionuevo , Augusto, Heredia, María Celeste, Caeiro, Juan Pablo, Fernández, Pehuén, Albertini, Ricardo Arturo
Formato: Artículo revista
Lenguaje:Español
Publicado: Universidad Nacional Córdoba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología 2021
Materias:
coronavirus infections
pneumonia
inpatients
prognosis
betacoronavirus
COVID-19
coronavirus
SARS-CoV-2
hospitalized patients
infecciones por coronavirus
neumonía
pacientes internos
pronóstico
pacientes hospitalizados
infecções por coronavirus
pacientes internados
prognóstico
coronavírus
Acceso en línea:https://revistas.unc.edu.ar/index.php/med/article/view/32518
Aporte de:
Revista de la Facultad de Ciencias Médicas de Córdoba de Universidad Nacional de Córdoba
Descripción
Sumario:Introduction: COVID-19 disease shows a marked heterogeneity in its clinical course, with descriptions of some factors associated with a worse prognosis. Knowledge of the disease behavior in the local scenario is relevant to allow a better approach.  Methods: Retrospective study in two hospitals in the city of Córdoba, Argentina, with patients aged 18 years or more, hospitalized for active SARS-CoV-2 infection, from March to October, 2020.  Results: 448 patients were included, of which 95.75% corresponded to COVID-19 pneumonia. Most of the episodes occurred in men (63.6%), the median age was 63 years (IQR: 53-75), and the most frequent comorbidities were arterial hypertension (55.1%), obesity (31.7%) and diabetes mellitus (28.1%). 162 patients (36.2%) needed admission to the intensive care unit and 66 (14.7%) were placed on mechanical ventilation. 67 patients (15%) died within the first 30 days of follow-up. In the multivariate analysis, the only independent variable predictive of mortality at 30 days was age (adjusted Odds ratio [aOR] = 1.08, 95% CI = 1.04-1.11, p <0.001). The 4C-Score and CALL-Score prognostic scores showed good discrimination (Area under the curve [AUC] = 0.766, 95% CI = 0.72-0.80 and AUC = 0.785, 95% CI = 0.70-0.85 respectively) and the predicted percentages of mortality were quite close to what was observed in the present study.  Conclusions: Most of the patients hospitalized with SARS-CoV-2 infection presented comorbidities and were admitted with pneumonia, associated with high mortality. The prognostic scores with the best performance to predict complications were the 4C-score and the CALL-score. 

Ejemplares similares