IL-6, MMP 3 and prognosis in previously healthy sepsis patients
Sepsis and septic shock are clinical conditions with high mortality despite advances in technology and are the leading cause of death in intensive care. Clinical manifestations and morbidity may be attributable to a disproportionate increase in proinflammatory cytokines. The aim of this study was to...
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Formato: | Artículo revista |
Lenguaje: | Inglés |
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Universidad Nacional Cba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología
2017
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Acceso en línea: | https://revistas.unc.edu.ar/index.php/med/article/view/14608 |
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Universidad Nacional de Córdoba |
institution_str |
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Revistas de la UNC |
language |
Inglés |
format |
Artículo revista |
topic |
Sepsis Cytokines Matrix Metalloproteases Interleukin 6 Prognosis Mortality |
spellingShingle |
Sepsis Cytokines Matrix Metalloproteases Interleukin 6 Prognosis Mortality Ricarte-Bratti, Juan Pablo Jaime-Albarrán, Nicolas Montrull, Hilda Lucrecia Brizuela, Nilda Yolanda IL-6, MMP 3 and prognosis in previously healthy sepsis patients |
topic_facet |
Sepsis Cytokines Matrix Metalloproteases Interleukin 6 Prognosis Mortality |
author |
Ricarte-Bratti, Juan Pablo Jaime-Albarrán, Nicolas Montrull, Hilda Lucrecia Brizuela, Nilda Yolanda |
author_facet |
Ricarte-Bratti, Juan Pablo Jaime-Albarrán, Nicolas Montrull, Hilda Lucrecia Brizuela, Nilda Yolanda |
author_sort |
Ricarte-Bratti, Juan Pablo |
title |
IL-6, MMP 3 and prognosis in previously healthy sepsis patients |
title_short |
IL-6, MMP 3 and prognosis in previously healthy sepsis patients |
title_full |
IL-6, MMP 3 and prognosis in previously healthy sepsis patients |
title_fullStr |
IL-6, MMP 3 and prognosis in previously healthy sepsis patients |
title_full_unstemmed |
IL-6, MMP 3 and prognosis in previously healthy sepsis patients |
title_sort |
il-6, mmp 3 and prognosis in previously healthy sepsis patients |
description |
Sepsis and septic shock are clinical conditions with high mortality despite advances in technology and are the leading cause of death in intensive care. Clinical manifestations and morbidity may be attributable to a disproportionate increase in proinflammatory cytokines. The aim of this study was to evaluate the ability to predict mortality from interleukin 6 [IL-6] and matrix metalloproteinase 3 [MMP-3]. This single-center, observational, prospective study included 48 adult patients admitted to the Hospital Nacional de Clinicas in Cordoba, Argentina, with sepsis or septic shock. Serum levels of IL-6 and MMP-3 were measured at the time of diagnosis and 72 hours later. At time of admission, MMP-3 was 13.77 mg/ml in patients who died and 10.55 mg/ml in patients who survived up to 28 days after hospitalization [p = 0.012], while IL-6 did not differ between the groups. The change in IL-6 over 72 hours was increased in nonsurvivors by 21.11 ± 11.81 pg/ml and decreased in survivors by 40.87 ± 14.94 pg/ml [p = 0.007]. No difference in the change of MMP-3 over 72 hours was observed between survivors and nonsurvivors. This study shows that MMP-3 at admission and the change in IL-6 over the first 72 hours of hospitalization could provide prognostic information in septic patients. Further studies are needed to define the utility of these cytokines as a measure of sepsis severity and as predictors of mortality. |
publisher |
Universidad Nacional Cba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología |
publishDate |
2017 |
url |
https://revistas.unc.edu.ar/index.php/med/article/view/14608 |
work_keys_str_mv |
AT ricartebrattijuanpablo il6mmp3andprognosisinpreviouslyhealthysepsispatients AT jaimealbarrannicolas il6mmp3andprognosisinpreviouslyhealthysepsispatients AT montrullhildalucrecia il6mmp3andprognosisinpreviouslyhealthysepsispatients AT brizuelanildayolanda il6mmp3andprognosisinpreviouslyhealthysepsispatients |
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Revistas |
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1764819781537497088 |