Maternal factors associated to congenital transmission of Chagas disease in children born and siblings in Chaco province, Argentina

Introduction. After vector-borne transmission, the congenital form is the most important to maintain the endemic. The probability of congenital transmission may depend on factors that vary between different countries and geographic areas. This study was carried out with the objective of estimating t...

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Autores principales: Chaparro, Raul Martin, Genero, Sebastian
Formato: Artículo revista
Lenguaje:Español
Publicado: Universidad Nacional Cba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología 2018
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Acceso en línea:https://revistas.unc.edu.ar/index.php/med/article/view/21260
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record_format ojs
institution Universidad Nacional de Córdoba
institution_str I-10
repository_str R-10
container_title_str Revistas de la UNC
language Español
format Artículo revista
topic chagas disease
trypanosoma cruzi infections
infectious disease transmission
vertical- disease neglected
enfermedad de chagas
trypanosoma cruzi
transmisión vertical de enfermedad infecciosa
morbilidad
spellingShingle chagas disease
trypanosoma cruzi infections
infectious disease transmission
vertical- disease neglected
enfermedad de chagas
trypanosoma cruzi
transmisión vertical de enfermedad infecciosa
morbilidad
Chaparro, Raul Martin
Genero, Sebastian
Maternal factors associated to congenital transmission of Chagas disease in children born and siblings in Chaco province, Argentina
topic_facet chagas disease
trypanosoma cruzi infections
infectious disease transmission
vertical- disease neglected
enfermedad de chagas
trypanosoma cruzi
transmisión vertical de enfermedad infecciosa
morbilidad
author Chaparro, Raul Martin
Genero, Sebastian
author_facet Chaparro, Raul Martin
Genero, Sebastian
author_sort Chaparro, Raul Martin
title Maternal factors associated to congenital transmission of Chagas disease in children born and siblings in Chaco province, Argentina
title_short Maternal factors associated to congenital transmission of Chagas disease in children born and siblings in Chaco province, Argentina
title_full Maternal factors associated to congenital transmission of Chagas disease in children born and siblings in Chaco province, Argentina
title_fullStr Maternal factors associated to congenital transmission of Chagas disease in children born and siblings in Chaco province, Argentina
title_full_unstemmed Maternal factors associated to congenital transmission of Chagas disease in children born and siblings in Chaco province, Argentina
title_sort maternal factors associated to congenital transmission of chagas disease in children born and siblings in chaco province, argentina
description Introduction. After vector-borne transmission, the congenital form is the most important to maintain the endemic. The probability of congenital transmission may depend on factors that vary between different countries and geographic areas. This study was carried out with the objective of estimating the proportion of congenital transmission of Chagas disease and maternal factors associated to the T. cruzi infection in newborns and their siblings during 2011 in four hospitals of the Province of Chaco. Methods. A cross sectional study was performed. A home visit was made to children aged above 10 months born during 2011 whom their mother present T cruzi infection. Blood samples were taken from both the newborns and their siblings and were processed for diagnosis of T. cruzi infection with HAI and ELISA. We found 247 mothers infected with T cruzi, and blood samples were obtained from 246 newborns and 556 of their siblings. Results. Of the 246 children born in 2011, a total of 6.1% (95% CI = 3.6-9.6) resulted with positive serology, as well as 7.7% of their siblings (95% CI = 5.7-10.1) and the clinic visits of those born in 2011 and their siblings in the health center was associated with a lower probability of congenital transmission (OR = 0.21 and 0.36, respectively). Conclusion. The transmission rate is consistent with the values reported in Argentina and only multiparity was a mother factor associated with the higher probability of congenital transmission.
publisher Universidad Nacional Cba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología
publishDate 2018
url https://revistas.unc.edu.ar/index.php/med/article/view/21260
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spelling I10-R10-article-212602020-02-26T20:24:06Z Maternal factors associated to congenital transmission of Chagas disease in children born and siblings in Chaco province, Argentina Transmisión congénita y factores maternos de la enfermedad de Chagas en niños al nacer y sus hermanos en la provincia del Chaco, Argentina Chaparro, Raul Martin Genero, Sebastian chagas disease trypanosoma cruzi infections infectious disease transmission vertical- disease neglected enfermedad de chagas trypanosoma cruzi transmisión vertical de enfermedad infecciosa morbilidad Introduction. After vector-borne transmission, the congenital form is the most important to maintain the endemic. The probability of congenital transmission may depend on factors that vary between different countries and geographic areas. This study was carried out with the objective of estimating the proportion of congenital transmission of Chagas disease and maternal factors associated to the T. cruzi infection in newborns and their siblings during 2011 in four hospitals of the Province of Chaco. Methods. A cross sectional study was performed. A home visit was made to children aged above 10 months born during 2011 whom their mother present T cruzi infection. Blood samples were taken from both the newborns and their siblings and were processed for diagnosis of T. cruzi infection with HAI and ELISA. We found 247 mothers infected with T cruzi, and blood samples were obtained from 246 newborns and 556 of their siblings. Results. Of the 246 children born in 2011, a total of 6.1% (95% CI = 3.6-9.6) resulted with positive serology, as well as 7.7% of their siblings (95% CI = 5.7-10.1) and the clinic visits of those born in 2011 and their siblings in the health center was associated with a lower probability of congenital transmission (OR = 0.21 and 0.36, respectively). Conclusion. The transmission rate is consistent with the values reported in Argentina and only multiparity was a mother factor associated with the higher probability of congenital transmission. Introducción. Luego de la transmisión vectorial, la congénita, es la forma más importante para mantener la endemia. La probabilidad de transmisión congénita puede depender de factores que varían entre los diferentes países y áreas geográficas. Se realizó este trabajo con el objetivo de estimar la proporción de transmisión congénita y explorar factores maternos asociados a la  enfermedad de Chagas en niños al nacer y sus respectivos hermanos en cuatro hospitales de la Provincia del Chaco. Métodos. Estudio transversal. Se realizó una visita al domicilio de niños de 10 meses de edad o mayores,  nacidos durante el año 2011, hijos de mujeres con infección por T cruzi. Se extrajeron muestras sanguíneas tanto de los niños al nacer como de sus hermanos y se procesaron para diagnóstico de infección por T cruzi con HAI y ELISA. Resultados. Se localizaron a 247 madres infectadas con T. cruzi, y se obtuvieron muestras de sangre de 246 niños al nacer y de 556 de sus hermanos. Del total de nacidos en el año 2011, el 6,1% (IC 95%= 3,6-9,6) resultaron con serología positiva,  así como 7,7%; de sus  hermanos (IC 95%= 5,7-10,1) y el control de salud de ambos niños en el centro de atención primaria  se asoció con una menor probabilidad de transmisión congénita (OR=0,21 y 0,36 respectivamente).Conclusión. La tasa de transmisión es consistente con los valores reportados en el país y solo la multiparidad fue un factor asociado a la mayor  probabilidad de transmisión congénita. Universidad Nacional Cba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología 2018-12-02 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf text/html application/vnd.openxmlformats-officedocument.spreadsheetml.sheet application/vnd.openxmlformats-officedocument.wordprocessingml.document https://revistas.unc.edu.ar/index.php/med/article/view/21260 Revista de la Facultad de Ciencias Médicas de Córdoba.; Vol. 75 No. 4 (2018); 279-287 Revista de la Facultad de Ciencias Médicas de Córdoba; Vol. 75 Núm. 4 (2018); 279-287 Revista da Faculdade de Ciências Médicas de Córdoba; v. 75 n. 4 (2018); 279-287 1853-0605 0014-6722 10.31053/1853.0605.v75.n4 spa https://revistas.unc.edu.ar/index.php/med/article/view/21260/22669 https://revistas.unc.edu.ar/index.php/med/article/view/21260/22675 https://revistas.unc.edu.ar/index.php/med/article/view/21260/27021 https://revistas.unc.edu.ar/index.php/med/article/view/21260/27022 Derechos de autor 2018 Universidad Nacional de Córdoba