Cell cycle inhibitor, p19INK4d, promotes cell survival and decreases chromosomal aberrations after genotoxic insult due to enhanced DNA repair
Genome integrity and cell proliferation and survival are regulated by an intricate network of pathways that includes cell cycle checkpoints, DNA repair and recombination, and programmed cell death. It makes sense that there should be a coordinated regulation of these different processes, but the com...
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| Formato: | Capítulo de libro |
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2007
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| LEADER | 17669caa a22018017a 4500 | ||
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| 001 | PAPER-6610 | ||
| 003 | AR-BaUEN | ||
| 005 | 20230518203618.0 | ||
| 008 | 190411s2007 xx ||||fo|||| 00| 0 eng|d | ||
| 024 | 7 | |2 scopus |a 2-s2.0-34047171404 | |
| 024 | 7 | |2 cas |a phosphorus 32, 14596-37-3; RNA, 63231-63-0; CDKN2D protein, human; Cdkn2d protein, mouse; Cyclin-Dependent Kinase Inhibitor p19; Pyrimidine Dimers; RNA, Messenger; Thymidine, 50-89-5 | |
| 040 | |a Scopus |b spa |c AR-BaUEN |d AR-BaUEN | ||
| 030 | |a DRNEA | ||
| 100 | 1 | |a Scassa, M.E. | |
| 245 | 1 | 0 | |a Cell cycle inhibitor, p19INK4d, promotes cell survival and decreases chromosomal aberrations after genotoxic insult due to enhanced DNA repair |
| 260 | |c 2007 | ||
| 270 | 1 | 0 | |m Cánepa, E.T.; Laboratorio de Biología Molecular, Departamento de Química Biológica, Facultad de Ciencias Exactas y Naturales, Ciudad Universitaria Pabellon II, 1428 Buenos Aires, Argentina; email: ecanepa@qb.fcen.uba.ar |
| 506 | |2 openaire |e Política editorial | ||
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| 520 | 3 | |a Genome integrity and cell proliferation and survival are regulated by an intricate network of pathways that includes cell cycle checkpoints, DNA repair and recombination, and programmed cell death. It makes sense that there should be a coordinated regulation of these different processes, but the components of such mechanisms remain unknown. In this report, we demonstrate that p19INK4d expression enhances cell survival under genotoxic conditions. By using p19INK4d-overexpressing clones, we demonstrated that p19INK4d expression correlates with the cellular resistance to UV treatment with increased DNA repair activity against UV-induced lesions. On the contrary, cells transfected with p19INK4d antisense cDNA show reduced ability to repair DNA damage and increased sensitivity to genotoxic insult when compared with their p19INK4d-overexpressing counterparts. Consistent with these findings, our studies also show that p19INK4d-overexpressing cells present not only a minor accumulation of UV-induced chromosomal aberrations but a lower frequency of spontaneous chromosome abnormalities than p19INK4d-antisense cells. Lastly, we suggest that p19INK4d effects are dissociated from its role as CDK4/6 inhibitor. The results presented herein support a crucial role for p19INK4d in regulating genomic stability and overall cell viability under conditions of genotoxic stress. We propose that p19INK4d would belong to a protein network that would integrate DNA repair, apoptotic and checkpoint mechanisms in order to maintain the genomic integrity. © 2007 Elsevier B.V. All rights reserved. |l eng | |
| 536 | |a Detalles de la financiación: Agencia Nacional de Promoción Científica y Tecnológica | ||
| 536 | |a Detalles de la financiación: Universidad de Buenos Aires | ||
| 536 | |a Detalles de la financiación: Consejo Nacional de Investigaciones Científicas y Técnicas | ||
| 536 | |a Detalles de la financiación: This work was partially supported by research grants from Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Agencia Nacional de Promoción Científica y Tecnológica (ANPCYT), and Universidad de Buenos Aires. MM, JC, AC and PS are Graduate Fellow and OP, MGC and EC are Research Members of CONICET. The authors would like to thank Zoraida Patrignani and Marcos Besio Moreno for the skillful technical assistance. | ||
| 593 | |a Laboratorio de Biología Molecular, Departamento de Química Biológica, Facultad de Ciencias Exactas y Naturales, Ciudad Universitaria Pabellon II, 1428 Buenos Aires, Argentina | ||
| 593 | |a Instituto de Investigaciones Hematológicas, Academia Nacional de Medicina, 1425 Buenos Aires, Argentina | ||
| 593 | |a Instituto de Biología y Medicina Experimental, CONICET, 1428 Buenos Aires, Argentina | ||
| 690 | 1 | 0 | |a APOPTOSIS |
| 690 | 1 | 0 | |a CELL SURVIVAL |
| 690 | 1 | 0 | |a CHROMOSOMAL ABERRATIONS |
| 690 | 1 | 0 | |a DNA REPAIR |
| 690 | 1 | 0 | |a GENOTOXIC |
| 690 | 1 | 0 | |a P19INK4D |
| 690 | 1 | 0 | |a COMPLEMENTARY DNA |
| 690 | 1 | 0 | |a CYCLIN DEPENDENT KINASE INHIBITOR 2D |
| 690 | 1 | 0 | |a PHOSPHORUS 32 |
| 690 | 1 | 0 | |a RNA |
| 690 | 1 | 0 | |a ANIMAL CELL |
| 690 | 1 | 0 | |a ARTICLE |
| 690 | 1 | 0 | |a CELL CYCLE |
| 690 | 1 | 0 | |a CELL GROWTH |
| 690 | 1 | 0 | |a CELL VIABILITY |
| 690 | 1 | 0 | |a CHROMOSOME ABERRATION |
| 690 | 1 | 0 | |a CLONOGENIC ASSAY |
| 690 | 1 | 0 | |a CONTROLLED STUDY |
| 690 | 1 | 0 | |a DNA DAMAGE |
| 690 | 1 | 0 | |a DNA RECOMBINATION |
| 690 | 1 | 0 | |a DNA REPAIR |
| 690 | 1 | 0 | |a DNA SYNTHESIS |
| 690 | 1 | 0 | |a FLOW CYTOMETRY |
| 690 | 1 | 0 | |a GENOTOXICITY |
| 690 | 1 | 0 | |a GROWTH INHIBITION |
| 690 | 1 | 0 | |a ISOTOPE LABELING |
| 690 | 1 | 0 | |a MOUSE |
| 690 | 1 | 0 | |a NONHUMAN |
| 690 | 1 | 0 | |a NORTHERN BLOTTING |
| 690 | 1 | 0 | |a POLYACRYLAMIDE GEL ELECTROPHORESIS |
| 690 | 1 | 0 | |a PRIORITY JOURNAL |
| 690 | 1 | 0 | |a PROTEIN CONTENT |
| 690 | 1 | 0 | |a TUMOR CELL CULTURE |
| 690 | 1 | 0 | |a ULTRAVIOLET IRRADIATION |
| 690 | 1 | 0 | |a WESTERN BLOTTING |
| 690 | 1 | 0 | |a ANIMALS |
| 690 | 1 | 0 | |a BLOTTING, NORTHERN |
| 690 | 1 | 0 | |a BLOTTING, WESTERN |
| 690 | 1 | 0 | |a CELL SURVIVAL |
| 690 | 1 | 0 | |a CHROMOSOME ABERRATIONS |
| 690 | 1 | 0 | |a COLONY-FORMING UNITS ASSAY |
| 690 | 1 | 0 | |a CYCLIN-DEPENDENT KINASE INHIBITOR P19 |
| 690 | 1 | 0 | |a DNA DAMAGE |
| 690 | 1 | 0 | |a DNA REPAIR |
| 690 | 1 | 0 | |a GENOMIC INSTABILITY |
| 690 | 1 | 0 | |a HUMANS |
| 690 | 1 | 0 | |a IMMUNOPRECIPITATION |
| 690 | 1 | 0 | |a MICE |
| 690 | 1 | 0 | |a PYRIMIDINE DIMERS |
| 690 | 1 | 0 | |a RADIATION TOLERANCE |
| 690 | 1 | 0 | |a RNA, MESSENGER |
| 690 | 1 | 0 | |a THYMIDINE |
| 690 | 1 | 0 | |a ULTRAVIOLET RAYS |
| 700 | 1 | |a Marazita, M.C. | |
| 700 | 1 | |a Ceruti, J.M. | |
| 700 | 1 | |a Carcagno, A.L. | |
| 700 | 1 | |a Sirkin, P.F. | |
| 700 | 1 | |a González-Cid, M. | |
| 700 | 1 | |a Pignataro, O.P. | |
| 700 | 1 | |a Cánepa, E.T. | |
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