Experimental porphyria induced in rats by hexachloro-benzene. A study of the porphyrins excreted by urine
Severe porphyria was induced and maintained for several months in rats by means of daily hexachlorobenzene administration via stomach tube. Urinary porphyrins with 8-, 7-, 6-, 5- and 4-COOH were isolated and studied by column and paper Chromatographic techniques, both qualitative and quantitative, a...
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1970
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| LEADER | 08489caa a22012977a 4500 | ||
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| 001 | PAPER-17843 | ||
| 003 | AR-BaUEN | ||
| 005 | 20230518204913.0 | ||
| 008 | 190411s1970 xx ||||fo|||| 00| 0 eng|d | ||
| 024 | 7 | |2 scopus |a 2-s2.0-0014768398 | |
| 024 | 7 | |2 cas |a chlorine, 13981-72-1, 7782-50-5; lindane, 58-89-9; porphyrin, 24869-67-8; Benzene Derivatives; Chlorine, 7782-50-5; Insecticides, Botanical; Lindane, 58-89-9; Porphyrins | |
| 040 | |a Scopus |b spa |c AR-BaUEN |d AR-BaUEN | ||
| 030 | |a CCATA | ||
| 100 | 1 | |a de Viale, L.C.S.M. | |
| 245 | 1 | 0 | |a Experimental porphyria induced in rats by hexachloro-benzene. A study of the porphyrins excreted by urine |
| 260 | |c 1970 | ||
| 270 | 1 | 0 | |m de Viale, L.C.S.M.; Departamento de Química Biológica, Orientatión Química Biológica I. Facultad de Ciencias Exactas y N aturales, Universidad de Buenos AiresArgentina |
| 506 | |2 openaire |e Política editorial | ||
| 504 | |a Schmid, Schwartz, Experimental Porphyria. III. Hepatic Type Produced by Sedormid. (1952) Experimental Biology and Medicine, 81, p. 685 | ||
| 504 | |a Case, Aldrich, Neve, Sedormid-Induced Porphyria in the Rat. (1953) Experimental Biology and Medicine, 83, p. 566 | ||
| 504 | |a Benard, Gajdos, Gajdos-Török, Compt. Rend. Soc. Biol. (1953) Compt. Rend. Soc. Biol., 147, p. 1591 | ||
| 504 | |a Goldberg, Rimington, Experimentally Produced Porphyria in Animals (1955) Proceedings of the Royal Society B: Biological Sciences, 143, p. 257 | ||
| 504 | |a Solomon, Figge, Disturbance in Porphyrin Metabolism Caused by Feeding Diethyl 1, 4-dihydro-2, 4, 6-trimethylpyridine-3, 5-dicarboxylate (1959) Experimental Biology and Medicine, 100, p. 583 | ||
| 504 | |a Tigier, Rivas, Grinstein, (1961) Rev. Soc. Argent. Biol., 37, p. 370 | ||
| 504 | |a Rimington, Ziegler, (1963) Biochem. Pharmacol., 12, p. 1387 | ||
| 504 | |a Granick, Urata, (1963) J. Biol. Chem., 238, p. 821 | ||
| 504 | |a De Matteis, Rimington, (1963) Brit. J. Dermatol., 75, p. 91 | ||
| 504 | |a Granick, (1966) J. Biol. Chem., 241, p. 1359 | ||
| 504 | |a Hirsch, Bubbar, Marks, (1967) Biochem. Pharmacol., 16, p. 1455 | ||
| 504 | |a Watson, (1954) Advances in Internal Medicine, 6, p. 235. , W. Dock, I. Snapper, Year Book Publishers, Chicago | ||
| 504 | |a Waldenstrom, (1957) Am. J. Med., 22, p. 758 | ||
| 504 | |a Goldberg, (1962) Panminerva Médica, 4, p. 328 | ||
| 504 | |a Granick, (1962) Trans. N.Y. Acad. Sci., 25, p. 53 | ||
| 504 | |a Goldberg, Rimington, (1962) Diseases of Porphyrin Metabolism, p. 231. , Charles C. Thomas, Springfield, Ill | ||
| 504 | |a Chisolm, Jr., (1964) J. Pediat., 64, p. 1 | ||
| 504 | |a Chisolm, Jr., (1964) J. Pediat., 64, p. 159 | ||
| 504 | |a Rimington, Porphyrin and Haem Biosynthesis and its Control (1966) Acta Medica Scandinavica, 179, p. 11 | ||
| 504 | |a Cam, (1959) Dirim (Istanbul), 34, p. 11 | ||
| 504 | |a Schmid, (1960) New Engl. J. Med., 263, p. 397 | ||
| 504 | |a Cetingil, Ozen, (1960) Blood, 16, p. 1002 | ||
| 504 | |a Schmid, (1962) Les Maladies du Métabolisme des Porphyrines, pp. 3-44. , Presse Universitaire de France, Paris | ||
| 504 | |a Cam, Nigogosyan, Acquired Toxic Porphyria Cutanea Tarda Due to Hexachlorobenzene (1963) JAMA, 183, p. 90 | ||
| 504 | |a Ockner, Schmid, (1961) Nature, 189, p. 499 | ||
| 504 | |a Gajdos, Gajdos-Török, Revue Franc. Études Clin. Biol. (1961) Revue Franc. Études Clin. Biol., 6, p. 549 | ||
| 504 | |a De Matteis, Prior, Rimington, (1961) Nature, 191, p. 363 | ||
| 504 | |a Gajdos, Gajdos-TörÖk, Compt. Rend. Soc. Biol. (1961) Compt. Rend. Soc. Biol., 155, p. 446 | ||
| 504 | |a Nacht, De Viale, Grinstein, (1970) Clin. Chim. Acta, 27, p. 445 | ||
| 504 | |a Nicholas, (1951) Biochem. J., 48, p. 309 | ||
| 504 | |a Grinstein, Schwartz, Watson, (1945) J. Biol. Chem., 157, p. 323 | ||
| 504 | |a Grinstein, Studies of protoporphyrin; a simple and improved method for the preparation of pure protoporphyrin from hemoglobin. (1947) J Biol Chem, 167, p. 515 | ||
| 504 | |a With, (1957) Nature, 179, p. 824 | ||
| 504 | |a Falk, Benson, (1953) Biochem. J., 55, p. 101 | ||
| 504 | |a Del C. Batlle, Grinstein, Porphyrin biosynthesis I. Studies on erythrocyte preparations (1964) Biochimica et Biophysica Acta (BBA) - General Subjects, 82, p. 1 | ||
| 504 | |a Eriksen, (1958) Scand. J. Clin. Lab. Invest., 10, p. 319 | ||
| 504 | |a Cornford, Benson, (1963) J. Chromatog., 10, p. 141 | ||
| 504 | |a Edmondson, Schwartz, (1953) J. Biol. Chem., 205, p. 605 | ||
| 504 | |a Salum, Del C. Batlle, Grinstein, (1961) Anales Asoc. Quím. Arg., 49, p. 3 | ||
| 504 | |a Del C. Batlle, Grinstein, (1962) Latin-Amer. Meeting Chem., 8th, Buenos Aires, Abstr., p. 107 | ||
| 504 | |a Watson, Schwartz, A Simple Test for Urinary Porphobilinogen. (1941) Experimental Biology and Medicine, 47, p. 393 | ||
| 504 | |a Raab, Pietschmann, Hartl, (1967) Arzneimittel-Forsch., 17, p. 985 | ||
| 504 | |a Nicholas, Rimington, (1951) Biochem. J., 50, p. 194 | ||
| 504 | |a Falk, (1963) Comprehensive Biochemistry, 9, p. 3. , M. Florkin, E.H. Stotz, Elsevier, Amsterdam | ||
| 504 | |a Chu, Chu, (1967) Clin. Chem., 13, p. 371 | ||
| 520 | 3 | |a Severe porphyria was induced and maintained for several months in rats by means of daily hexachlorobenzene administration via stomach tube. Urinary porphyrins with 8-, 7-, 6-, 5- and 4-COOH were isolated and studied by column and paper Chromatographic techniques, both qualitative and quantitative, and their absorption spectra and melting points were determined. It was found that the relative excretory pattern was: uroporphyrin > coproporphyrin > phyriaporphyrins > 5-COOH porphyrin > 6-COOH porphyrin. By chemical decarboxylation, all these porphyrins were found to be the type III isomer with only traces of uroporphyrin I and 5-COOH porphyrin I. The predominant porphyrins in the liver were uroporphyrin III and phyriaporphyrin. These findings were compared with those reported in humans intoxicated with the same chemical and with those in patients with hepatic porphyria cutanea tarda. The main differences among these groups were in the isomeric composition of the uroporphyrin, 5-COOH porphyrin and coproporphyrin. Porphyria induced in rats by hexachlorobenzene appears to provide a useful experimental approach for the study of the metabolic changes involved in human porphyria. © 1970. |l eng | |
| 536 | |a Detalles de la financiación: This work was supported in part by a research grant from Consejo National de Investigaciones Cientificas y Tecnicas, Argentina. | ||
| 593 | |a Departamento de Química Biológica, Orientatión Química Biológica I. Facultad de Ciencias Exactas y N aturales, Universidad de Buenos Aires, Argentina | ||
| 690 | 1 | 0 | |a BENZENE DERIVATIVE |
| 690 | 1 | 0 | |a CHLORINE |
| 690 | 1 | 0 | |a INSECTICIDE |
| 690 | 1 | 0 | |a LINDANE |
| 690 | 1 | 0 | |a PORPHYRIN |
| 690 | 1 | 0 | |a ANIMAL |
| 690 | 1 | 0 | |a ARTICLE |
| 690 | 1 | 0 | |a CHROMATOGRAPHY |
| 690 | 1 | 0 | |a FEMALE |
| 690 | 1 | 0 | |a HUMAN |
| 690 | 1 | 0 | |a IATROGENIC DISEASE |
| 690 | 1 | 0 | |a MALE |
| 690 | 1 | 0 | |a METABOLISM |
| 690 | 1 | 0 | |a MICROPHOTOGRAPHY |
| 690 | 1 | 0 | |a PAPER CHROMATOGRAPHY |
| 690 | 1 | 0 | |a PORPHYRIA |
| 690 | 1 | 0 | |a RAT |
| 690 | 1 | 0 | |a SPECTROPHOTOMETRY |
| 690 | 1 | 0 | |a URINE |
| 690 | 1 | 0 | |a ANIMAL |
| 690 | 1 | 0 | |a BENZENE DERIVATIVES |
| 690 | 1 | 0 | |a CHLORINE |
| 690 | 1 | 0 | |a CHROMATOGRAPHY |
| 690 | 1 | 0 | |a CHROMATOGRAPHY, PAPER |
| 690 | 1 | 0 | |a FEMALE |
| 690 | 1 | 0 | |a HUMAN |
| 690 | 1 | 0 | |a INSECTICIDES, BOTANICAL |
| 690 | 1 | 0 | |a LINDANE |
| 690 | 1 | 0 | |a MALE |
| 690 | 1 | 0 | |a PHOTOMICROGRAPHY |
| 690 | 1 | 0 | |a PORPHYRIA |
| 690 | 1 | 0 | |a PORPHYRINS |
| 690 | 1 | 0 | |a RATS |
| 690 | 1 | 0 | |a SPECTROPHOTOMETRY |
| 700 | 1 | |a Viale, A.A. | |
| 700 | 1 | |a Nacht, S. | |
| 700 | 1 | |a Grinstein, M. | |
| 773 | 0 | |d 1970 |g v. 28 |h pp. 13-23 |k n. 1 |p Clin. Chim. Acta |x 00098981 |w (AR-BaUEN)CENRE-907 |t Clinica Chimica Acta | |
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| 856 | 4 | 0 | |u https://hdl.handle.net/20.500.12110/paper_00098981_v28_n1_p13_deViale |y Handle |
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