Studies on porphyrin biosynthesis in lead-intoxicated rabbits
The present report deals with studies on porphyrins and porphyrinogen carboxylyase of red cells and urinary porphyrins from lead-intoxicated rabbits. It was shown that the free erythrocyte porphyrins are a mixture of protoporphyrin 9, the main component, and minor proportions of Coproporphyrin, Urop...
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| Formato: | Capítulo de libro |
| Lenguaje: | Inglés |
| Publicado: |
1976
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| Acceso en línea: | Registro en Scopus DOI Handle Registro en la Biblioteca Digital |
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| LEADER | 04703caa a22006737a 4500 | ||
|---|---|---|---|
| 001 | PAPER-12334 | ||
| 003 | AR-BaUEN | ||
| 005 | 20230518204232.0 | ||
| 008 | 190411s1976 xx ||||fo|||| 00| 0 eng|d | ||
| 024 | 7 | |2 scopus |a 2-s2.0-0017136142 | |
| 024 | 7 | |2 cas |a porphyrin, 24869-67-8; uroporphyrinogen decarboxylase, 9024-70-8; Porphyrinogens; Porphyrins; Uroporphyrinogen Decarboxylase, EC 4.1.1.37 | |
| 040 | |a Scopus |b spa |c AR-BaUEN |d AR-BaUEN | ||
| 030 | |a CCATA | ||
| 100 | 1 | |a De Viale, L.C.S.M. | |
| 245 | 1 | 0 | |a Studies on porphyrin biosynthesis in lead-intoxicated rabbits |
| 260 | |c 1976 | ||
| 270 | 1 | 0 | |m Grinstein, M. |
| 506 | |2 openaire |e Política editorial | ||
| 504 | |a Haeger-Aronson, (1960) Scand. J. Clin. Lab. Invest., 126 | ||
| 504 | |a Chisolm, (1964) J. Pediatr., 64, p. 174 | ||
| 504 | |a Kreimer-Birnbaum, Grinstein, (1965) Biochim. Biophys. Acta, 111, p. 110 | ||
| 504 | |a Garcia, San Martín de Viale, Tomio, Grinstein, (1973) Biochim. Biophys. Acta, 309, p. 203 | ||
| 504 | |a Aragones, Garcia, San Martín de Viale, Tomio, Grinstein, (1972) An. Asoc. Quim. Arg., 60, p. 239 | ||
| 504 | |a Falk, Benson, (1953) Biochem. J., 55, p. 101 | ||
| 504 | |a Salum, Del C. Batlle, Grinstein, (1961) An. Asoc. Quim. Arg., 49, p. 3 | ||
| 504 | |a Grinstein, Watson, (1943) J. Biol. Chem., 147, p. 675 | ||
| 504 | |a Tomio, Garcia, San Martín de Viale, Grinstein, (1970) Biochim. Biophys. Acta, 198, p. 353 | ||
| 504 | |a Mauzerall, Granick, (1958) J. Biol. Chem., 232, p. 1141 | ||
| 504 | |a Schmid, Hanson, Schwarz, Experimental Porphyria. I. Isolation of Uroporphyrin I from Bone Marrow of Lead Poisoned Rabbits. (1952) Experimental Biology and Medicine, 79, p. 459 | ||
| 504 | |a Steiner, Baldini, Dameshek, (1964) Ann. N.Y. Acad. Sci., 119, p. 548 | ||
| 504 | |a Doss, (1973) Enzymes, 16, p. 231 | ||
| 520 | 3 | |a The present report deals with studies on porphyrins and porphyrinogen carboxylyase of red cells and urinary porphyrins from lead-intoxicated rabbits. It was shown that the free erythrocyte porphyrins are a mixture of protoporphyrin 9, the main component, and minor proportions of Coproporphyrin, Uroporphyrin III and Phyriaporphyrin. Analysis of the urinary porphyrins demonstrates the presence of Coproporphyrin III as the major component, together with 15-20% of other porphyrins: 10-14% 5-COOH, 1-2% 6-COOH, 2-3% 7-COOH porphyrin and 1-2% Uroporphyrin III. We have not been able to detect an increase of Uroporphyrin I. Assays of porphyrinogen carboxy-lyase activity in hemolysate supernatant using Uroporphyrinogen III and Phyriaporphyrinogen (Phyria'gen) III as substrates, showed the existence of a slight decrease of both decarboxylase activities, being more affected during the second stage, the Phyria'gen decarboxylation. A possible regulation mechanism responsible for the porphyrin picture is discussed. © 1976. |l eng | |
| 536 | |a Detalles de la financiación: The technical assistanceo f Mrs. Carmen Aldonatti de Olivar and Mr. F. Ortega is gratefully acknowledged. Part of this work was supported by a research grant from Consejo National de Investigaciones Cientificas y Tecnicas, Argentina. | ||
| 593 | |a Laboratorio de Porfirinas, Departamento de Química Biológica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Pabellón II, 4 piso, Ciudad Universitaria, Núñez, Buenos Aires Argentina | ||
| 690 | 1 | 0 | |a PORPHYRIN |
| 690 | 1 | 0 | |a UROPORPHYRINOGEN DECARBOXYLASE |
| 690 | 1 | 0 | |a IN VITRO STUDY |
| 690 | 1 | 0 | |a LEAD POISONING |
| 690 | 1 | 0 | |a THEORETICAL STUDY |
| 690 | 1 | 0 | |a ANIMAL |
| 690 | 1 | 0 | |a ERYTHROCYTES |
| 690 | 1 | 0 | |a FEMALE |
| 690 | 1 | 0 | |a LEAD POISONING |
| 690 | 1 | 0 | |a MALE |
| 690 | 1 | 0 | |a PORPHYRINOGENS |
| 690 | 1 | 0 | |a PORPHYRINS |
| 690 | 1 | 0 | |a RABBITS |
| 690 | 1 | 0 | |a UROPORPHYRINOGEN DECARBOXYLASE |
| 700 | 1 | |a De Calmanovici, R.W. | |
| 700 | 1 | |a De Molina, M.D.C.R. | |
| 700 | 1 | |a Grinstein, M. | |
| 773 | 0 | |d 1976 |g v. 69 |h pp. 375-382 |k n. 3 |p Clin. Chim. Acta |x 00098981 |w (AR-BaUEN)CENRE-907 |t Clinica Chimica Acta | |
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| 856 | 4 | 0 | |u https://doi.org/10.1016/0009-8981(76)90108-X |y DOI |
| 856 | 4 | 0 | |u https://hdl.handle.net/20.500.12110/paper_00098981_v69_n3_p375_DeViale |y Handle |
| 856 | 4 | 0 | |u https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00098981_v69_n3_p375_DeViale |y Registro en la Biblioteca Digital |
| 961 | |a paper_00098981_v69_n3_p375_DeViale |b paper |c PE | ||
| 962 | |a info:eu-repo/semantics/article |a info:ar-repo/semantics/artículo |b info:eu-repo/semantics/publishedVersion | ||
| 999 | |c 73287 | ||