Saccharomyces cerevisiae article priority journal cyclic AMP dependent protein kinase nonhuman controlled study Cyclic AMP-Dependent Protein Kinases PKA Saccharomyces cerevisiae Proteins unclassified drug SACCHAROMYCES CEREVISIAE enzyme active site in vivo study Phosphorylation enzyme activation glucose Catalytic Domain Enzyme Activation Glucose Isoenzymes Yeast enzyme activity enzymology gene deletion genetics holoenzyme metabolism Cyclic AMP-Dependent Protein Kinase Catalytic Subunits Gene Expression Regulation, Fungal Saccharomyces cerevisiae protein