building BDUCA
institution Biblioteca Digital (UCA)
id BDUCA--investigacion:orthostatic-hypotension-parkinson
author Pérez Lloret, Santiago
Rey, Verónica
Pavy-Le Traon, Anne
Rascol, Olivier
spellingShingle Pérez Lloret, Santiago
Rey, Verónica
Pavy-Le Traon, Anne
Rascol, Olivier
HIPOTENSION ORTOSTATICA
ENFERMEDAD DE PARKINSON
EPIDEMIOLOGIA
MEDICINA BASADA EN EVIDENCIA
FLUDROCORTISONA
Orthostatic hypotension in Parkinson's disease
Summary: Orthostatic hypotension (OH) is a frequent non-motor symptom in Parkinson’s Disease (PD) affecting between 22.9 and 38.4% of patients. OH is related in PD to increased risk of falls and possibly to cognitive dysfunction and increased mortality. These data emphasizes the importance of its prompt recognition and treatment. OH is related to pre-ganglionic and post-ganglionic adrenergic denervation, but other factors such as drugs, heat, meals or alcohol intake might also induce or aggravate it. Evidence about the efficacy and safety of pharmacological or non-pharmacological strategies for OH treatment in PD is weak. Non-pharmacological measures include liberal addition of salt to the diet, exercise, compression stocking or physical maneuvers. Severe cases may be treated with midodrine or fludrocortisone. Some results suggest that droxidopa and fipamezole might be effective treatments. We finish this review article by discussing the most important unanswered questions about PD-related OH, which might be the focus of future research
author2 Toulouse University Hospital
Universidad Católica Argentina. Laboratorio de Farmacología y Epidemiología
topic HIPOTENSION ORTOSTATICA
ENFERMEDAD DE PARKINSON
EPIDEMIOLOGIA
MEDICINA BASADA EN EVIDENCIA
FLUDROCORTISONA
topic_facet HIPOTENSION ORTOSTATICA
ENFERMEDAD DE PARKINSON
EPIDEMIOLOGIA
MEDICINA BASADA EN EVIDENCIA
FLUDROCORTISONA
title Orthostatic hypotension in Parkinson's disease
title_full Orthostatic hypotension in Parkinson's disease
title_fullStr Orthostatic hypotension in Parkinson's disease
title_full_unstemmed Orthostatic hypotension in Parkinson's disease
title_short Orthostatic hypotension in Parkinson's disease
contents Summary: Orthostatic hypotension (OH) is a frequent non-motor symptom in Parkinson’s Disease (PD) affecting between 22.9 and 38.4% of patients. OH is related in PD to increased risk of falls and possibly to cognitive dysfunction and increased mortality. These data emphasizes the importance of its prompt recognition and treatment. OH is related to pre-ganglionic and post-ganglionic adrenergic denervation, but other factors such as drugs, heat, meals or alcohol intake might also induce or aggravate it. Evidence about the efficacy and safety of pharmacological or non-pharmacological strategies for OH treatment in PD is weak. Non-pharmacological measures include liberal addition of salt to the diet, exercise, compression stocking or physical maneuvers. Severe cases may be treated with midodrine or fludrocortisone. Some results suggest that droxidopa and fipamezole might be effective treatments. We finish this review article by discussing the most important unanswered questions about PD-related OH, which might be the focus of future research
url http://bibliotecadigital.uca.edu.ar/repositorio/investigacion/orthostatic-hypotension-parkinson.pdf
format Artículo
genre Artículo
genre_facet Artículo
era 2013
era_facet 2013
publishDate 2013
language English
_version_ 1630392005248942080
score 12,815243